Requirements in patients with pre-existing hypoproteinemia or hepatic impairment may be greater. Individualize dosage based on careful monitoring of clinical parameters in all patient populations. Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed. Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.
Albumin is a transparent or slightly opalescent solution which may have a greenish tint or may vary from pale straw to amber color. Albumin may be given undiluted. Acceptable diluents include 0. Do not mix or add with other medicinal products including blood and blood components, protein hydrolysates, or solutions containing alcohol.
Do not add supplementary medication. Storage: Administer within 4 hours of entering the container. More rapid administration can cause circulatory overload and pulmonary edema. Generic: - Store below 86 degrees F Albuked : - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion.
Do not store for later use. Albumarc: - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion.
Albuminar: - Discard product if it contains particulate matter, is cloudy, or discolored - Store between 68 to 77 degrees F, excursions permitted 59 to 86 degrees F Albuminex: - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Do not freeze - Protect from light - Store in carton AlbuRx : - Discard product if it contains particulate matter, is cloudy, or discolored - Store at room temperature not exceeding 86 degrees F Albutein: - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion.
Buminate: - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion. Flexbumin: - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion. Macrotec: - Refrigerate between 36 and 46 degrees F Plasbumin: - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion.
Use of albumin is contraindicated in patients with a history of albumin hypersensitivity or hypersensitivity to any of the excipients. Discontinue administration immediately and institute appropriate medical treatment if a hypersensitivity reaction is suspected.
Albumin is contraindicated in patients with severe anemia or heart failure with normal or increased intravascular volume. Monitor coagulation and hematology parameters when large volumes are replaced. Ensure adequate substitution of other blood constituents e. Monitor electrolyte status and take appropriate steps to address electrolyte imbalance. Discontinue albumin administration at the first sign of cardiovascular overload e. Albumin increases plasma volume and can cause vascular overload, especially after rapid infusion.
Maintenance of plasma colloid osmotic pressure and carriage of intermediated products in the transport and exchange of tissue metabolites. Maintenance of plasma colloid osmotic pressure and carriage of intermediate products in the transport and 3exchange of tissue metabolites. Use in patients with fluid or sodium restrictions e.
Albumin is a plasma-derived blood product. Albumin may be prescribed as a bolus dose, where a patient requires an Albumin infusion over a discrete period of time and the total dose is known.
A continuous infusion is sometimes used when a patient needs an Albumin infusion for an extended period of time and when the clinician does not know exactly when the infusion will cease. In this instance it should be prescribed as a regular administration e. Two clinicians must independently complete the patient and blood product identification check at the bedside.
Record the batch number and expiry date of each bottled infused in the medical record. Staff administering Albumin must also record the date, time and volume infused. Administer via a standard intravenous IV giving set. It does not require a transfusion filter. The manufacturer recommends that each bottle of Albumin is used immediately after opening the bottle as it does not contain antimicrobial preservative.
If there has been considerable loss of red blood cells, transfusion with packed red blood cells is indicated. Albumin or Albumin in either normal saline or dextrose is indicated to prevent marked hemoconcentration and to maintain appropriate electrolyte balance.
Albumin is indicated in those clinical situations usually associated with a low concentration of plasma protein and a resulting decreased circulating blood volume. Although diuresis may occur soon after albumin administration has been instituted, best results are obtained if albumin is continued until the normal serum protein level is regained.
Do not use if the solution is turbid. Since this product contains no antimicrobial preservative, do not begin administration more than 4 hours after the container has been entered. Discard partially used vials. Products made from human plasma may contain infectious agents such as viruses, that can cause disease. Stringent procedures utilized at plasma collection centers, plasma testing laboratories, and fractionation facilities are designed to reduce the risk of viral transmission.
Despite these measures, such products may still potentially contain human pathogenic agents, including those not yet known or identified. Thus the risk of transmission of infectious agents cannot be totally eliminated.
Any infections thought by a physician possibly to have been transmitted by this product should be reported by the physician or other healthcare provider to CSL Behring at The physician should discuss the risks and benefits of this product with the patient. Albumin is a derivative of human blood. Based on effective donor screening and product manufacturing processes, it carries an extremely remote risk for transmission of viral diseases. A theoretical risk for transmission of Creutzfeldt-Jakob disease CJD also is considered extremely remote.
No cases of transmission of viral diseases or CJD have ever been identified for albumin. If dehydration is present additional fluids must accompany or follow the administration of albumin.
Administration of large quantities of albumin should be supplemented with or replaced by packed red blood cells to combat the relative anemia which would follow such use. The quick response of blood pressure which may follow the rapid administration of concentrated albumin necessitates careful observation of the injured patient to detect bleeding points which failed to bleed at lower blood pressure.
If anaphylactic or severe anaphylactoid reactions occur, discontinue infusion immediately. Infusion rates and the patient's clinical state should be monitored closely during infusion.
0コメント