Not a significant difference. This seems to be the one metric where injecting HGH 7-days per week benefits you over injection 3-days per week. See discussion below. Lean Thigh Mass: The 3-day HGH injection group saw more increased muscle mass in their thighs, while both the 7-day HGH injection group and the placebo group saw no measurable increase. For men, this may be of interest, since larger thigh muscle mass is often associated with higher serum testosterone levels.
Bone Mineral Density: No group saw an increase in bone mineral density. However, this study was done in Korea using the Korean population. Their diet is much different than the Standard American Diet SAD , and other western culture diets, so more than likely their cholesterol levels and lipids were already relatively good, so not a lot of improvement could be made anyway.
As the study shows us, when it comes to HGH injections, more is not necessarily better. In fact, it may impede athletic performance.
Although more investigation is required, it is possible that too high a dose too frequently injection may produce a limited amount of HGH resistance.
We know this from a growing number of insulin-resistant pre-diabetes epidemic we now see unfolding in modern society due to frequent over-feeding, creating high levels of hyperinsulinemia. The one major difference between the two groups was in body fat reduction. The 7-dau HGH injection group saw 2. Besides this difference, those on a limited budget may find injecting HGH 3 — 4 days a week will save you money and will save you money.
One such study done in , investigated patients divided into three groups. Group 3: 3 IUs per day, 6-days per week for year 1, then 4. Year 1: Height velocity doubled in the 4. In the second year, height velocity no longer changed among the groups, as they were all taking similar dosages at that stage. Other similar studies have been done in children and generally, show similar results.
The conclusions of the study stated the following: During 4 years of rhGH therapy, growth and final height prognosis improved, slightly more with 4. However, bone age advanced on average 4. Because of studies such as these which were done with children, many physicians and practitioners still think higher IUs mean better results. It likely due to the higher IGF-1 Axis and its growing impact in bones.
When growth hormone increases combined with high protein diets, IGF-1 increases from growth hormone metabolized in the liver, but also from high protein metabolism.
However, other research suggests that IGF-1 may be pro-cancer and pro-aging in adults, while lower IGF-1 may be of benefit for aging adults. However, if too much concentration is placed on IGF-1 increases, then many can be missing the point in gaining maximum benefit from their therapy. In addition, HGH is the most expensive form of hormone replacement therapy.
Properly dosing to maximize benefit, is why patients should choose the right anti-aging medical group to support them in their treatment. Minimizing cancer risk is important by monitoring IGF-1 levels, diet and nutrition, and ensuring proper doses improve lean muscle mass, blood lipids, energy and other benefits as to be expected with HGH replacement therapy.
For those concerned mostly about managing fat loss. Get more information and speak with one of our age management experts on how we can structure an affordable program that works best for you and your budget. If stored in the refrigerator after first use the Norditropen HGH pen will last for 4 weeks. Anti-Aging and Wellness is your trusted source for medical tourism.
We concentrate on medically supervised wellness. Our focus is on optimizing cellular metabolism with lifestyle, BHRT, and cellular-based therapies. Anti-Aging and Wellness Medical. It is not intended to diagnose, treat or cure any health-related condition. Please always consult a physician regarding your health before starting any health or diet program. No medical treatment can guarantee results.
Results vary among individuals. We encourage you to do your own research, ask questions, and review board certifications and testimonials on any similar websites describing similar therapies. Please review our Terms of Use for more information. GH treatment is also contraindicated during pregnancy and lactation. In patients with tumours, anti-tumour therapy must be completed before starting GH therapy.
The cost of treatment reduces with age because the GH requirement decreases as people get older. Costs may vary in different settings because of negotiated procurement discounts. Home NICE Guidance Conditions and diseases Diabetes and other endocrinal, nutritional and metabolic conditions Metabolic conditions Human growth hormone somatropin in adults with growth hormone deficiency Technology appraisal guidance [TA64] Published: 27 August In fact, clinical trials have revealed that the weight-based method can lead to overdosing and side effects in patients who are overweight or obese.
In such cases, starting with 0. The dose should be taken once per day, days per week, to emulate the natural pulsatile release of growth hormone in the human body.
It takes at least a month of therapy for growth hormone injections to start working. The first noticeable benefits include fat loss around the abdomen and an increase in lean body weight. According to scientific evidence , it takes six months or more for the majority of benefits to occur such as improved mood, higher energy levels, and better quality of life.
Usually, GH therapy is applied as a short-term treatment in these conditions, which is why the recommendations are for considerably higher doses compared to the ones used in GHD. Also, higher doses are used from the start of the therapy and there is no gradual increase.
The dosage can be administered daily or any other day for up to 12 weeks. According to trials in HIV patients , common adverse effects due to high HGH doses include elevated blood sugar, edema, and pain in muscles and joints. The optimal dosage for patients with GHD varies from 0. It depends on factors such as the length of HGH therapy, individual tolerance, effectiveness, and risk of side effects.
Group 3 used 0. The three groups were equal with regard to age, sex, and body mass index. After 12 weeks of treatment, IGF-I levels were low normal in the low dose group and normal in groups 2 and 3 of both adult-onset and childhood-onset GHD. This study demonstrates differences in the biochemical characteristics of childhood-onset and adult-onset GHD. GH therapy at doses of 0. This dose could, therefore, be a starting dose in GH-deficient adults.
It became apparent that GH treatment in GH-deficient adults does have beneficial effects on body composition, quality of life, and bone mass 1 — 4. Initial studies of GH replacement in hypopituitary adults used high daily GH doses 0. However, these studies were associated with a high incidence of side-effects mainly salt and water retention , which usually responded to a reduction in the dose 5. In sequential studies using half this dose 0.
Using lower doses in adults than in children is also in agreement with the lower physiological GH production in adults than in children. Moreover, the physiological GH production in adulthood decreases with age 7 — A dose between 0.
We used doses calculated on the basis of estimations of physiological GH production. Sixty patients were randomized to 0. All three groups started at a rhGH dose of 0. Thirty GH-deficient males and 30 GH-deficient females mean age, 47 yr; range, 23—70 yr were studied.
The cause of GHD in 7 of the 9 patients with a childhood-onset GHD was idiopathic or related to birth trauma 3 of them had been treated with GH before for 3—6 yr. The other 2 patients had craniopharyngioma and germinoma in childhood both treated with GH for 5 and 2 yr, respectively. Three patients had isolated GHD. Patients were treated with conventional substitution when indicated. Informed consent was obtained from all subjects, and the study was approved by the ethics committee of Leiden University Hospital.
At the start of the study they were randomized to one of the three dose groups: group 1 used 0. Blood was withdrawn at the start of the study and after 4, 8, and 12 weeks of rhGH therapy. The detection limit was 1. Age-related normal data were determined in the same laboratory. IGF-I was also expressed as a sd score from age-related normal levels. Serum samples were diluted times. The interassay coefficient of variation was below 6. The limit of detection was 0.
Normative data were based on 54 healthy control subjects aged 20—70 yr. Standards were human biosynthetic GH Pharmacia diluted in bovine calf serum and calibrated against the WHO First International Reference Preparation 80— to convert micrograms per L to milliunits per L, multiply by 2. The detection limit of the assay was 0. A paired t test was used to test for significant differences within a dose group in time.
In Table 1 , the characteristics of the patients in the three groups are shown. The groups were equal with regard to age, sex, height, weight, body mass index, and severity of GHD, estimated by the maximum GH concentration measured during ITT.
Data are given as the mean sem. GH is the maximum GH concentration during insulin-induced hypoglycemia. All subjects completed the study. The rhGH dose was not increased to 1. The first patient was a yr-old male height, He developed carpal tunnel syndrome after 5 weeks of rhGH treatment 4 weeks of 0.
His serum IGF-I level at the start of treatment was 9. The second patient was a yr-old male height, He developed fluid retention problems after 5 weeks of treatment 4 weeks of 0. His serum IGF-I level at the start of treatment was 7.
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